报告题目：Advancing CNS Repair and Neuroplasticity through Cutting-Edge Nano-Drug Delivery Systems and Stem Cell Therapies

主讲人：KiBum Lee 教授

主持人：王慎强 教授

时间：2024年10月28日 9：00

地点：云轩楼2108会议室

专家简介

KiBum Lee is a distinguished professor of chemistry and chemical biology at Rutgers University, where he has been a faculty member since 2008. He received his Ph.D. in Chemistry from Northwestern University (with Chad. A. Mirkin; 2004) and completed his postdoctoral training at The Scripps Research Institute (with Peter G. Schultz; 2007) respectively. The primary research interest of his group is to develop and integrate nanotechnologies and chemical biology to modulate signaling pathways in stem cells and cancer cells toward specific cell lineages or behaviors. He has received external grant funding mainly as a PI (~19.1 million dollars) at Rutgers since 2008. He has published approximately 152 articles in high-profile journals, including Science, Cell Stem Cell, Nat. Commun., J. Am. Chem. Soc., Angew. Chem, Int. Ed., Adv. Mater., and Chem. Rev., which are highly cited (>13,000).

 

报告简介

This presentation will explore the intersection of nanomedicine, chemical biology, and stem cell therapeutics in the context of neural repair. Neurological disorders often lead to severe, permanent paralysis due to cellular dysfunction. The central nervous system (CNS) has limited regenerative capacity, and damaged tissues present a complex inhibitory environment, posing significant challenges for repair. This presentation explores the convergence of nanomedicine, chemical biology, and stem cell therapeutics as a promising approach to CNS regeneration. Our research focuses on three key strategies:(i) developing a non-viral genetic manipulation method mimicking natural transcription factors to control neuronal functions, (ii) creating a nanomaterial-based bioscaffold for controlled in vivo delivery of therapeutic molecules, and (iii) integrating nano-bioscaffold technology with stem cell transplantation to enhance survival, differentiation, and functional integration of transplanted cells, promoting neuroplasticity and CNS regeneration.